Concomitant psychiatric problems and hormonal treatment induced metabolic syndrome in gender dysphoria individuals: A 2 year follow-up study

Costa, Rosalia and Colizzi, Marco and Scaramuzzi, Francesca and Palumbo, Claudia and Tyropani, Margarita and Pace, Valeria and Quagliarella, Luca and Brescia, Francesco and Natilla, Lilia Carmen and Loverro, Giuseppe and Todarello, Orlando (2015) Concomitant psychiatric problems and hormonal treatment induced metabolic syndrome in gender dysphoria individuals: A 2 year follow-up study. Journal of Psychosomatic Research . ISSN 0022-3999

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Abstract/Book Review

Objective: Several studies indicate increased prevalence of metabolic syndrome (MetS) among patients with psychiatric disorders as well as among individuals with gender dysphoria (GD) treated by cross-sex hormonal treatment. However, the MetS prevalence among hormone treated GD individuals suffering from psychiatric problems has not been detected. Methods: From a sample of 146 GD patients we selected 122 metabolically healthy individuals in order to investigate the prevalence of MetS after the beginning of the cross-sex hormonal treatment in a 2 year follow-up assessment. Furthermore, we assessed differences in MetS prevalence between hormone treated GD patients with and without concomitant psychiatric problems. Results: When treated with hormone therapy, GD patients reported changes in several parameters which are clustered in MetS, with statistically significant differences compared to baseline. Glyco-insulinemic alterations were more pronounced in male to female patients (MtFs). However, weight gain, waist circumference increases, blood pressure increases, and lipid alterations were similar in MtFs and female to male patients (FtMs). 14.8% of the sample at year 1 and 17.2% at year 2 developed MetS. Among patients with concomitant psychiatric problems, 50% at year 1 and 55% at year 2 developed MetS against 8% at year 1 and 10% at year 2 of patients without concomitant psychiatric problems. Conclusion: This study indicates that sex hormones induce MetS in a relatively low proportion of healthy GD individuals and especially during the first year of hormonal treatment. Most importantly, concomitant psychiatric problems are associated with considerably greater MetS prevalence in hormone treated GD individuals.

Item Type: Article
Additional Information: Available online: 10 February 2015
Uncontrolled Keywords: Gender Dysphoria, Hormone Replacement Therapy, Concomitant Psychiatric Problems, Metabolic Syndrome.
Subjects: Research, Tests, Assessments > Psychological Research
Sex Psychology > Gender Identity
Department/People: Special Units
Depositing User: Ms Jocelyn Wade
Date Deposited: 12 Mar 2015 13:42
Last Modified: 16 Mar 2015 09:37

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